Boltz

Boltz Skills

Run Boltz biomolecular workflows — structure prediction, binding, molecular and protein screening, and de novo design — directly from your AI coding agent. The skills shell out to the boltz-api CLI to create inputs, estimate cost, submit jobs, and download results.

📖 Full guide: Agent integrations for the Boltz API

Supported agents

For Codex and Claude Code, use the official marketplace plugins. Gemini CLI has a native extension, and Claude Desktop uses the MCPB server. Vercel Skills provides an additional way to install the shared skills in Antigravity and other supported agents, or in environments where you prefer a direct skill installation.

Skills

Skill	What it does
boltz-cli-setup	Install, update, verify, and authenticate the boltz-api CLI.
boltz-structure-and-binding	Predict the 3D structure of a defined complex; optionally score binding.
boltz-small-molecule-screen	Rank a SMILES library against a target.
boltz-small-molecule-design	Generate novel small-molecule binders.
boltz-small-molecule-adme	Estimate Tier-1 ADME (solubility, permeability, logD) from bare SMILES.
boltz-protein-screen	Rank proteins / peptides / antibodies against a target.
boltz-protein-design	Generate novel peptide / antibody / nanobody / custom-protein binders.
boltz-check-status	List and inspect jobs; recover results after an interrupted session.

Prerequisites

All surfaces need the boltz-api CLI on your PATH.

macOS and Linux:

curl -fsSL https://install.boltz.bio/boltz-api/install.sh | sh

Windows PowerShell:

irm https://install.boltz.bio/boltz-api/install.ps1 | iex

Verify it:

boltz-api --version

Then authenticate, using either device-code login or an API key:

boltz-api auth login --device-code
# or
export BOLTZ_API_KEY="your-api-key"

Results download to a boltz-experiments/ directory in your working directory (created automatically). Point any command at a different location with --root-dir.

Install

Codex and Claude Code (recommended: official plugins)